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Proceedings Paper

Intracellular uptake kinetics of hypocrellin photosensitizers for photodynamic therapy
Author(s): Gerald G. Miller; Kevin Brown; Ronald B. Moore; Zhenjun Diwu; Jixiang Liu; Liren Huang; J. William Lown; David A. Begg; Vera Chlumecky; John Tulip; Malcolm S. McPhee
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Paper Abstract

Hypocrellins are naturally occurring compounds with photosensitizing properties in biological systems. We have prepared synthetic derivatives of hypocrellin B, which have promise as photosensitizers in the clinical application of photodynamic therapy. The inherent fluorescence of four selected compounds has provided a means of determining their uptake and distribution in monolayer cultures of EMT6/Ed murine tumor cells, via fluorescence confocal microscopy.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203432
Show Author Affiliations
Gerald G. Miller, Cross Cancer Institute (Canada)
Kevin Brown, Cross Cancer Institute (Canada)
Ronald B. Moore, Cross Cancer Institute (Canada)
Zhenjun Diwu, Molecular Probes, Inc. (United States)
Jixiang Liu, Univ. of Alberta (Canada)
Liren Huang, Univ. of Alberta (Canada)
J. William Lown, Univ. of Alberta (Canada)
David A. Begg, Univ. of Alberta (Canada)
Vera Chlumecky, Univ. of Alberta (Canada)
John Tulip, Univ. of Alberta (Canada)
Malcolm S. McPhee, Cross Cancer Institute (Canada)


Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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