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Proceedings Paper

Effectiveness of photodynamic therapy with a diode laser using mono-L-aspartyl chlorin e6 for implanted fibrosarcoma in mice
Author(s): Tohichiro Katsumi; Katsuo Aizawa; Yukari Kuroiwa; Yoshiteru Ii; Kouichi Saito; X. Ilyar; Tetsuya Okunaka; Chimori Konaka; Harubumi Kato
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Paper Abstract

The authors developed a new high power red laser diode system for photodynamic therapy (PDT) with Mono-L-aspartyl Chlorin e6 (NPe6). The laser beam has a low wavelength (664 nm) and relatively high power. Our results suggest that a certain increase in the tumor tissue level of NPe6 and a certain increase of laser light dose reaching a deeper layer of tumor caused an increase in percent cure. In addition, the effectiveness of PDT and also tumor recurrence following PDT depend to some extent on the total laser dose reaching deeper layers of tumors. Furthermore, the effectiveness of PDT tends to correlate with the amount of photobleaching by PDT.

Paper Details

Date Published: 1 March 1995
PDF: 4 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203430
Show Author Affiliations
Tohichiro Katsumi, Tokyo Medical College (Japan)
Katsuo Aizawa, Tokyo Medical College (Japan)
Yukari Kuroiwa, Tokyo Medical College (Japan)
Yoshiteru Ii, Matsushita Industrial Equipment Co., Ltd. (Japan)
Kouichi Saito, Tokyo Medical College (Japan)
X. Ilyar, Tokyo Medical College (Japan)
Tetsuya Okunaka, Tokyo Medical College (Japan)
Chimori Konaka, Tokyo Medical College (Japan)
Harubumi Kato, Tokyo Medical College (Japan)


Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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