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Proceedings Paper

Treatment of experimental murine arthritis with transdermal photodynamic therapy
Author(s): Leslie G. Ratkay; R. K. Chowdhary; Herma C. Neyndorff; Julia G. Levy; J. D. Waterfield
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Paper Abstract

Photodynamic therapy (PDT) using benzoporphyrin derivative, monoacid ring A (BPD), and transdermal light was able to significantly treat symptoms of adjuvant-enhanced arthritis in MRL-lpr mice. Clinical and histological evaluation showed that PDT was able to modify the progression of adjuvant-enhanced arthritis up to 10 days after induction. When PDT was used on arthritic joints displaying swelling, it prevented further deterioration of clinical symptoms (76%, 16/21). However, it did not significantly effect the histopathologic parameters. As we have previously reported that mitogen activated MRL-lpr splenocytes were shown to be more susceptible to in vitro PDT we postulate that our findings reflect a selective destruction of adjuvant activated lymphocytes in the circulation and/or joints. The application of PDT to eliminate activated cells responsible for the inflammatory reaction at the arthritic site may have significant clinical implications for the treatment of rheumatoid arthritis.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203424
Show Author Affiliations
Leslie G. Ratkay, Quadra Logic Technologies Inc. and Univ. of British Columbia (Canada)
R. K. Chowdhary, Univ. of British Columbia (Canada)
Herma C. Neyndorff, Quadra Logic Technologies Inc. (Canada)
Julia G. Levy, Quadra Logic Technologies Inc. and Univ. of British Columbia (Canada)
J. D. Waterfield, Univ. of British Columbia (Canada)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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