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Proceedings Paper

Brain response to photodynamic therapy and Photofrin, nonsulfonated aluminum phthalocyanine and tin purpurin
Author(s): Mary O. Dereski; Lara Madigan; Michael Chopp
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Paper Abstract

Photodynamic therapy (PDT) with PhotofrinR, nonsulfonated aluminum phthalocyanine (AlClPc), and tin ethyl etiopurpurin I (SnET2) was investigated on normal and tumored (9L gliosarcoma) rat brain. Rats were injected 48 h prior to PDT (3 - 280 J/cm2, 100 mW/cm2) with PhotofrinR (12.5 mg/kg) and AlClPc (2.0 mg/kg) and 24 h prior with SnET2 (1.0 mg/kg). Substantial lesions were present in normal brain with PhotofrinR and with AlClPc at all energy levels. No lesions were present with SnET2. Tumor response for PhotofrinR and AlClPc did not occur with doses less than 140 J/cm2. Drug concentrations for tumored/contralateral hemisphere for PhotofrinR and AlClPc were 1.86 and 7.86, respectively. These data indicate: (1) normal brain is more sensitive than the tumored brain with PhotofrinR and AlClPc, and (2) normal brain sensitivity to SnET2 is less than that with PhotofrinR and AlClPc.

Paper Details

Date Published: 1 March 1995
PDF: 3 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203420
Show Author Affiliations
Mary O. Dereski, Henry Ford Hospital (United States)
Lara Madigan, Henry Ford Hospital (United States)
Michael Chopp, Henry Ford Hospital and Oakland Univ. (United States)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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