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Proceedings Paper

Percutaneous transluminal photodynamic therapy of atheroma using mono-L-aspartyl chlorin e6
Author(s): Junichi Hayashi; Hideaki Sato; Takashi Saito; Yukari Kuroiwa; Katsuo Aizawa; Tatsushi Fujiwara; Yasuhiro Hosoda
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Paper Abstract

Structural changes after photodynamic therapy of atherosclerotic lesions of the thoracic aorta were analyzed by scanning electron microscopy. Cholesterol fed atherosclerotic rabbits were injected intravenously with 5 mg/kg of NPe6. At 6 hours after NPe6 loading, a diode laser irradiated angioscopically on the surface of atheroma with the total energy of 200 mJ/cm2. Scanning electron microscopy showed degeneration of atherosclerotic plaques of the thoracic aorta examined at one week after photodynamic therapy. NPe6 could be a potent photosensitizer for photodynamic therapy of atheroma.

Paper Details

Date Published: 1 March 1995
PDF: 4 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203414
Show Author Affiliations
Junichi Hayashi, Kyorin Univ. (Japan)
Hideaki Sato, Kyorin Univ. (Japan)
Takashi Saito, Kyorin Univ. (Japan)
Yukari Kuroiwa, Tokyo Medical College (Japan)
Katsuo Aizawa, Tokyo Medical College (Japan)
Tatsushi Fujiwara, Keio Univ. (Japan)
Yasuhiro Hosoda, Keio Univ. (Japan)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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