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Proceedings Paper

Endoscopic fluorescence of gastrointestinal neoplasia after sensitization with 5-aminolaevulinic acid (ALA) or Photofrin
Author(s): Helmut Messmann; Peter Mlkvy; Sune Montan; Ingrid Wang-Nordman; Annika M.K. Nilsson; Katarina Svanberg; Sune Svanberg; Alexander J. MacRobert; Stephen G. Bown
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Paper Abstract

Fluorescence after photosensitization has the potential to identify lesions not visible on conventional endoscopy. We assessed 12 patients at high risk of or with established GI cancers (u ulcerative colitis, 1 colon polyp, 2 familial polyposis with duodenal polyps, 2 early oesophageal cancers). Fluorescence images (excitation 390 nm) were recorded with endoscopic equipment and additional spot measurements (optical multichannel analyzer). Patients were given 10 - 60 mg/kg ALA orally or 2 mg/kg Photofrin i.v. 60 mg/kg ALA gave high levels of PP IX (proto-porphyrin IX) in all areas, but 10 - 15 mg/kg resulted in selectivity in macroscopically inflamed colon. Photofrin gave oesophageal tumors selectivity at 4 and 48 hours. Photofrin patients subsequently had PDT. Photobleaching was documented in 3. We conclude that these techniques have potential as `optical biopsy tools' and for screening for early neoplastic changes.

Paper Details

Date Published: 1 March 1995
PDF: 4 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203402
Show Author Affiliations
Helmut Messmann, Univ. Regensburg (Germany)
Univ. College London Medical School (United Kingdom)
Peter Mlkvy, National Cancer Ctr. (Slovak Republic)
Univ. College London Medical School (United Kingdom)
Sune Montan, Spectraphos Lund (Sweden)
Ingrid Wang-Nordman, Univ. of Lund (Sweden)
Annika M.K. Nilsson, Univ. of Lund (Sweden)
Katarina Svanberg, Univ. of Lund (Sweden)
Sune Svanberg, Univ. of Lund (Sweden)
Alexander J. MacRobert, Univ. College London Medical School (United Kingdom)
Stephen G. Bown, Univ. College London Medical School (United Kingdom)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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