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Proceedings Paper

Meso-tetrahydroxyphenylchlorin (mTHPC) fluorescence kinetics in mice
Author(s): Laurent Morlet; Veronique Vonarx-Coinsmann; Marie-Therese Foultier; Thierry Patrice
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Paper Abstract

Analysis of sensitizer kinetics is essential for the performance of light irradiation when tumor concentration and tumor-to-normal tissue ratios are optimal. In our study, nude mice were grafted with human adenocarcinoma 15 days before m-THPC IP injection. Fluorescence was recorded through an optic fiber spectrofluorometer at 650, the most intense, and 714 nm, and intensity was proportional to the injected dose. In tumor, skin and muscle, maximum fluorescence was obtained with 1.6 mg/kg 72 h after injection (44 counts per second). Tumor- to-skin and -muscle ratios obtained by HPLC analysis and spectrofluorometric measurements decreased between 12 and 72 h (15 to 1.5), indicating that tumor selectivity decreases with time.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203401
Show Author Affiliations
Laurent Morlet, Hopital Laennec (France)
Veronique Vonarx-Coinsmann, Hopital Laennec (France)
Marie-Therese Foultier, Hopital Laennec (France)
Thierry Patrice, Hopital Laennec (France)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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