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Proceedings Paper

Photodynamic therapy induced leukocyte adherence in normal subcutaneous, but not in tumor microvessels
Author(s): Marc Dellian; Christoph Abels; Gerhard E.H. Kuhnle; Alwin E. Goetz
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Paper Abstract

Leukocyte mediated tissue damage is proposed to contribute to the tumoricidal effect of photodynamic therapy (PDT). To elucidate this hypothesis leukocyte-endothelium interaction and red blood cell velocity in the microvasculature of an amelanotic melanoma and normal tissue in a skin fold chamber preparation were investigated before and after PDT (5 mg/kg PhotofrinR; 630 nm; 10 or 100 J/cm2). One hour after PDT (10 and 100 J/cm2) the number of adhering leukocytes increased in subcutaneous but not in tumor microvessels. At this time red blood cell velocity remained unaltered in microvessels of subcutaneous tissue but decreased (10 J/cm2) and even ceased (100 J/cm2) in tumor microvessels. These results indicate that tumor destruction induced by PDT is not mediated by leukocyte-endothelium interaction.

Paper Details

Date Published: 1 March 1995
PDF: 4 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203393
Show Author Affiliations
Marc Dellian, Ludwig-Maximilians-Univ. Muenchen (Germany)
Christoph Abels, Ludwig-Maximilians-Univ. Muenchen (Germany)
Gerhard E.H. Kuhnle, Ludwig-Maximilians-Univ. Muenchen (Germany)
Alwin E. Goetz, Ludwig-Maximilians-Univ. Muenchen (Germany)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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