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Proceedings Paper

Photodynamic therapy (PDT) for locally recurrent breast carcinoma
Author(s): Johannes Gahlen; Josef Stern; Georgi Graschew; Michael R. Kaus; Christian Herfarth
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Paper Abstract

Locally recurrent breast carcinoma and skin metastasisses on the chest wall can be difficult to treat. Conventional treatments like radiation-, chemo- and hormonal therapy have shown poor results in these patients. In comparison to this, PDT has some advantages and less side effects. We can observe a tumor accumulation of a systemic applied photosensitizer (PS). The PS can be stimulated by light of a wavelength of 630 nm and a phototoxic effect in the tumor occurs. We treated 7 patients with locally recurrent breast carcinoma 15 times with PDT. The intravenous application of the PS (Photofrin II, 1.5 mg/kg BW) was done 24 - 96 hours before local laser light radiation. The light source was an Ar-Dye laser with a wavelength of 630 nm. Due to a local tumor necrosis we observed a tumor reduction in each case. In 5 patients we saw a complete local remission with a good cosmetic result. Side effects were rare. All patients suffered from pain in the treated area. No major phototoxicity effects were seen. PDT can induce complete local tumor remissions in patients with cutaneous metastasisses after locally recurrent breast carcinoma. In absence of other metastasisses PDT is possibly a curative treatment. One of the major advantages of this treatment are the rare side effects, rare complications and the possible repetition of the PDT.

Paper Details

Date Published: 1 March 1995
PDF: 3 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203390
Show Author Affiliations
Johannes Gahlen, Chirurgische Universitaetsklinic Heidelberg and Deutsches Krebsforschungs (Germany)
Josef Stern, Chirurgische Universitaetsklinic Heidelberg and Deutsches Krebsforschungs (Germany)
Georgi Graschew, Chirurgische Universitaetsklinic Heidelberg and Deutsches Krebsforschungs (Germany)
Michael R. Kaus, Chirurgische Universitaetsklinic Heidelberg and Deutsches Krebsforschungs (Germany)
Christian Herfarth, Chirurgische Universitaetsklinic Heidelberg and Deutsches Krebsforschungs (Germany)


Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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