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Proceedings Paper

Photodynamic effect on specific antitumor immune activity
Author(s): Veronique Vonarx-Coinsmann; Marie-Therese Foultier; Laurent Morlet; Leonor Xavier de Brito; Thierry Patrice
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Paper Abstract

In this study the effect of PDT on the antitumoral specific immunologic response was evaluated. We compared the specific cytolytic activity (CLA) by a chromium release assay of primed mouse spleen T lymphocytes sensitized against syngeneic mastocytoma P511 cells. P511 cells, or lymphocytes, or both cells were treated or not with photofrin and/or light (514 nm). Photofrin II alone (1 (mu) g/ml, 2 hours) reduced CLA 59% when P511 were treated. Photofrin II (1 (mu) g/ml) followed by light (25 Joules/sq cm) also reduced CLA 35%. Photofrin II alone (0.5 (mu) g/ml, 2 hours) reduced CLA 8% when only lymphocytes were treated. And Photofrin II (0.5 (mu) g/ml) followed by light (25 Joules/sq cm) also reduced CLA 45%. When both cells were treated with Photofrin II alone or followed by light (25 Joules/sq cm) the CLA was also reduced respectively 19, 41%.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203377
Show Author Affiliations
Veronique Vonarx-Coinsmann, Hopital Laennec (France)
Marie-Therese Foultier, Hopital Laennec (France)
Laurent Morlet, Hopital Laennec (France)
Leonor Xavier de Brito, Hopital Laennec (France)
Thierry Patrice, Hopital Laennec (France)


Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting

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