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Proceedings Paper

Photodynamic therapy with cationic photosensitizers
Author(s): David Kessel; Kathryn W. Woodburn; Chi Kwong Chang; Barbara W. Henderson
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Paper Abstract

We characterized sites of photodamage catalyzed by two cationic photosensitizers tetrabromo- rhodamine 123 (TBR), which is recognized by the multidrug transporter, and a monocationic porphyrin (MCP), which is not. The transporter is an outward transport system associated with examples of drug resistance. Irradiation of multidrug-resistant cells treated with TBR resulted in highly selective photodamage to the transporter site, while MCP catalyzed non- specific membrane damage to cells regardless of transporter expression.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203370
Show Author Affiliations
David Kessel, Wayne State Univ. School of Medicine (United States)
Kathryn W. Woodburn, Wayne State Univ. School of Medicine (United States)
Chi Kwong Chang, Michigan State Univ. (United States)
Barbara W. Henderson, Roswell Park Cancer Institute (United States)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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