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Proceedings Paper

Evaluation with mTHPC of early squamous cell carcinomas of the cheek pouch mucosa of Golden Syrian hamsters as a model for clinical PDT of early cancers in the upper aerodigestive tract, the esophag
Author(s): Thomas M. Glanzmann; Jean-Francois Theumann; Martin Forrer; Daniel Braichotte; Georges A. Wagnieres; Hubert van den Bergh; Snezana Andrejevic-Blant; Jean-Francois Savary; Philippe Monnier
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Paper Abstract

Golden Syrian hamsters are evaluated as an animal model for light induced fluorescence (LIF) photodetection and phototherapy of early squamous cell carcinomas of the upper aerodigestive tract, the esophagus, and the traecheo-bronchial tree. Carcinomas of this type are induced on the hamster cheek pouch mucosa by the application of the carcinogen 7,12-DMBA. For phototherapeutic experiments on the animals we utilized meso-(tetrahydoxyphenyl) chlorin (mTHPC). This drug is currently in phase I and II clinical trials for ENT patients presenting superficial `early' squamous cell carcinomas. By means of LIF we measured in vivo the kinetics of the uptake and removal of mTHPC in the normal and tumoral cheek mucosa and in the skin. The photodynamic therapy (PDT) reaction of the tissue after excitation of the photosensitizer with laser light at 652 nm was studied. Both pharmacokinetics and PDT efficacy are compared between animal model and clinical results with special emphasis on selectivity between normal and tumoral mucosa. These first experiments show that this tumor model in the hamster cheek pouch seems to be suitable for testing new photosensitizers preceding their clinical application as well as for optimization of the multiple parameters of clinical PDT.

Paper Details

Date Published: 1 March 1995
PDF: 8 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203366
Show Author Affiliations
Thomas M. Glanzmann, Swiss Federal Institute of Technology (Switzerland)
Jean-Francois Theumann, Swiss Federal Institute of Technology (Switzerland)
Martin Forrer, Swiss Federal Institute of Technology (Switzerland)
Daniel Braichotte, Swiss Federal Institute of Technology (Switzerland)
Georges A. Wagnieres, Swiss Federal Institute of Technology (Switzerland)
Hubert van den Bergh, Swiss Federal Institute of Technology (Switzerland)
Snezana Andrejevic-Blant, CHUV Hospital (Switzerland)
Jean-Francois Savary, CHUV Hospital (Switzerland)
Philippe Monnier, CHUV Hospital (Switzerland)


Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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