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Proceedings Paper

Tumor responses after combined PDT and hyperthermia
Author(s): Fred W. Hetzel; H. Chen; Qun Chen
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Paper Abstract

The objective of this study is to investigate tumor responses when treated with the combination of photodynamic therapy and hyperthermia. Intra-tumoral oxygen levels (pO2) and 30 day tumor regrowth were investigated. C3H murine mammary leg tumors were implanted and grown to a diameter of 6 mm. The combined treatment was designed based on the data from our previous studies of tumor response and tumor tissue oxygen levels after various doses of hyperthermia and PDT alone. Photofrin (12.5 mg/kg, i.p.) was administered to the animals 24 hours before light treatment (630 nm, 200 J/cm2, 300 mW/cm2). Hyperthermia (43.5 degree(s)C, 30 to 90 minutes) was delivered 4 hours after the PDT treatment. TCD60 and TCD80 were observed for the combined therapy with 60 and 90 min hyperthermia, in comparison to the TCD10 and TCD20 for the hyperthermia alone, respectively. The results indicate that improved therapeutic results can be achieved with the combined therapy designed based on the tissue PO2 profiles after single modality treatment.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203362
Show Author Affiliations
Fred W. Hetzel, Presbyterian/St. Luke's Medical Ctr. (United States)
H. Chen, Presbyterian/St. Luke's Medical Ctr. (United States)
Qun Chen, Presbyterian/St. Luke's Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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