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Proceedings Paper

Effects of laser-exposed gold nanorods on biochemical pathways of neuronal cells
Author(s): Chiara Paviolo; John W. Haycock; Paul R. Stoddart; Sally L. McArthur
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Paper Abstract

Gold nanorods with citrate termination, poly(4 - styrenesulfonic acid) coating and silica coating were taken up by NG108 - K15 neuronal cells. This process proved to generate reactive oxygen species (ROS) and activate the nuclear factor κ -B (NF - κB). However, subsequent exposure to laser light at the plasmon resonance wavelength showed no long term cell damage or ROS / NF- κB activation. Interestingly, monitoring of intracellular Ca2+ signaling showed evidence of photo - generated transients without alteration of other normal cell functions. These results suggest new opportunities for peripheral nerve regeneration treatments and for infrared neural stimulation.

Paper Details

Date Published: 7 December 2013
PDF: 9 pages
Proc. SPIE 8923, Micro/Nano Materials, Devices, and Systems, 89231A (7 December 2013); doi: 10.1117/12.2033575
Show Author Affiliations
Chiara Paviolo, Swinburne Univ. of Technology (Australia)
John W. Haycock, The Univ. of Sheffield (United Kingdom)
Paul R. Stoddart, Swinburne Univ. of Technology (Australia)
Sally L. McArthur, Swinburne Univ. of Technology (Australia)

Published in SPIE Proceedings Vol. 8923:
Micro/Nano Materials, Devices, and Systems
James Friend; H. Hoe Tan, Editor(s)

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