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Proceedings Paper

Temperature controlled retinal photocoagulation
Author(s): Kerstin Schlott; Stefan Koinzer; Alexander Baade; Reginald Birngruber; Johann Roider; Ralf Brinkmann
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Paper Abstract

Retinal photocoagulation lacks objective dosage in clinical use, thus the commonly applied lesions are too deep and strong, associated with pain reception and the risk of visual field defects and induction of choroidal neovascularisations. Optoacoustics allows real-time non-invasive temperature measurement in the fundus during photocoagulation by applying short probe laser pulses additionally to the treatment radiation, which excite the emission of ultrasonic waves. Due to the temperature dependence of the Grüneisen parameter, the amplitudes of the ultrasonic waves can be used to derive the temperature of the absorbing tissue. By measuring the temperatures in real-time and automatically controlling the irradiation by feedback to the treatment laser, the strength of the lesions can be defined. Different characteristic functions for the time and temperature dependent lesion sizes were used as rating curves for the treatment laser, stopping the irradiation automatically after a desired lesion size is achieved. The automatically produced lesion sizes are widely independent of the adjusted treatment laser power and individual absorption. This study was performed on anaesthetized rabbits and is a step towards a clinical trial with automatically controlled photocoagulation.

Paper Details

Date Published: 14 June 2013
PDF: 8 pages
Proc. SPIE 8800, Opto-Acoustic Methods and Applications, 880009 (14 June 2013); doi: 10.1117/12.2033416
Show Author Affiliations
Kerstin Schlott, Medical Laser Ctr. Lübeck (Germany)
Institute of Biomedical Optics (Germany)
Stefan Koinzer, Univ. Kiel (Germany)
Alexander Baade, Medical Laser Ctr. Lübeck (Germany)
Reginald Birngruber, Medical Laser Ctr. Lübeck (Germany)
Institute of Biomedical Optics (Germany)
Johann Roider, Univ. Kiel (Germany)
Ralf Brinkmann, Medical Laser Ctr. Lübeck (Germany)
Institute of Biomedical Optics (Germany)

Published in SPIE Proceedings Vol. 8800:
Opto-Acoustic Methods and Applications
Vasilis Ntziachristos; Charles P. Lin, Editor(s)

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