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Proceedings Paper

Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging
Author(s): James A. Guggenheim; Hector R. A. Basevi; Iain B. Styles; Jon Frampton; Hamid Dehghani
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Paper Abstract

A study is presented that demonstrates that bioluminescence tomography can reconstruct accurate 3D images of internal light sources placed at a range of depths within a physical phantom and that it provides more reliable quantitative data than standard bioluminescence imaging. Specifically, it is shown that when imaging sources at depths ranging from 5 to 15mm, estimates of total source strength are stable to within ±11% using tomography whilst values deduced by traditional methods vary 10-fold. Additionally, the tomographic approach correctly localises sources to within 1.5mm error in all cases considered.

Paper Details

Date Published: 14 June 2013
PDF: 6 pages
Proc. SPIE 8799, Diffuse Optical Imaging IV, 87990G (14 June 2013); doi: 10.1117/12.2033317
Show Author Affiliations
James A. Guggenheim, The Univ. of Birmingham (United Kingdom)
Hector R. A. Basevi, The Univ. of Birmingham (United Kingdom)
Iain B. Styles, The Univ. of Birmingham (United Kingdom)
Jon Frampton, The Univ. of Birmingham (United Kingdom)
Hamid Dehghani, The Univ. of Birmingham (United Kingdom)


Published in SPIE Proceedings Vol. 8799:
Diffuse Optical Imaging IV
Paola Taroni; Hamid Dehghani, Editor(s)

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