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Proceedings Paper

Water-soluble benzylidene cyclopentanone photosensitizers for two-photon excited photodynamic therapy
Author(s): Yanyan Fang; Hongyou Zhao; Qianli Zou; Yuxia Zhao; Ying Gu; Feipeng Wu
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Paper Abstract

A series of benzylidene cyclopentanone photosensitizers modified by polyethylene glycol, carboxylate anionic or pyridyl cationic groups with gradient lipid-water partition coefficients were reported. Detailed characterization and systematic studies of these photosensitizers, including their linear and nonlinear photophysical properties, in vitro photodynamic therapy (PDT) and two-photon excited PDT (2PE–PDT) activities were conducted and compared with a clinical drug PSD-007 (a mixture of porphyrins). Three of them exhibited appropriate lipid-water partition coefficients, high reactive oxygen yields, large two-photon absorption cross-section and low dark toxicity under therapy dosage, could be absorbed efficiently by liver hepatocellular HepG2 cells and presented strong PDT and 2PE-PDT activity by in vitro cell experiments. Furthermore, in vivo tumor experiments were carried out on BALB/c mouse models using B3 as the photosensitizer. The results showed that the tumor growth could be effectively suppressed by B3 under 2PE-PDT. This work demonstrated the feasibility of using a simple molecular structure to construct high efficient photosensitizers for 2PE-PDT.

Paper Details

Date Published: 7 December 2013
PDF: 9 pages
Proc. SPIE 8923, Micro/Nano Materials, Devices, and Systems, 892319 (7 December 2013); doi: 10.1117/12.2033302
Show Author Affiliations
Yanyan Fang, Technical Institute of Physics and Chemistry (China)
Graduate Univ. of Chinese Academy of Sciences (China)
Hongyou Zhao, Chinese PLA General Hospital (China)
Qianli Zou, Technical Institute of Physics and Chemistry (China)
Graduate Univ. of Chinese Academy of Sciences (China)
Yuxia Zhao, Technical Institute of Physics and Chemistry (China)
Ying Gu, Chinese PLA General Hospital (China)
Feipeng Wu, Technical Institute of Physics and Chemistry (China)

Published in SPIE Proceedings Vol. 8923:
Micro/Nano Materials, Devices, and Systems
James Friend; H. Hoe Tan, Editor(s)

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