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Proceedings Paper

Experimental research of the possible use of photodynamic methods in the treatment of melanoma of the iris
Author(s): Tadeusz Kecik; Iwona Switka-Wieclawska; Jan Kasprzak; Alfreda Graczyk; Antoni Pratnicki
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Paper Abstract

In our experimental work we present the use of hematoporphyrin derivative photodynamic therapy (HpD-PDT) in the treatment of melanoma. Eighteen eyes of rabbits were incubated intracamerally with amelanotic Greene melanoma tissue. The technique involves the administration of HpD and photoactivation of tumor with red light (630 nm) to achieve selective destruction of cancer cells. After photoradiation the tumor showed blanching and shrinkage, we could also observe the tumor vasculature damaged. Successfully treated tumors had large areas of necrosis with severely damaged blood vessels in histopathological examination. Results indicate that HpD-PDT is a very promising modern modality offering a new method of melanoma treatment.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2203, Laser Technology IV: Applications in Medicine, (1 March 1995); doi: 10.1117/12.203328
Show Author Affiliations
Tadeusz Kecik, Medical Academy in Warsaw (Poland)
Iwona Switka-Wieclawska, Medical Academy in Warsaw (Poland)
Jan Kasprzak, Medical Academy in Warsaw (Poland)
Alfreda Graczyk, Medical Academy in Warsaw (Poland)
Antoni Pratnicki, Medical Academy in Warsaw (Poland)


Published in SPIE Proceedings Vol. 2203:
Laser Technology IV: Applications in Medicine
Wieslaw L. Wolinski; Tadeusz Kecik, Editor(s)

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