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Proceedings Paper

High-resolution deep-tissue optical imaging using anti-Stokes phosphors
Author(s): A. P. Popov; A. V. Karmenyan; A. V. Bykov; E. V. Khaydukov; A. V. Nechaev; O. A. Bibikova; V. Ya. Panchenko; V. A. Semchishen; V. N. Seminogov; A. S. Akhmanov; V. I. Sokolov; M. T. Kinnunen; V. V. Tuchin; A. V. Zvyagin
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Paper Abstract

We report on the high-resolution deep-tissue imaging using novel water-dispersible upconversion nanoparticles (UCNPs) β-NaYF4:Yb3+:Tm3+. Luminescence from the UCNP embedded into tissue-mimicking phantoms at the depth of 4 mm epi-illuminated with 975-nm laser radiation was detected. Fiber-optic detection shows 2-times better resolution compared with that obtained using CCD-based imaging modality. The conversion efficiency of upconversion particles and their cytotoxicity to HeLa cells were also investigated and reported.

Paper Details

Date Published: 18 June 2013
PDF: 8 pages
Proc. SPIE 8801, Novel Biophotonic Techniques and Applications II, 88010C (18 June 2013); doi: 10.1117/12.2032805
Show Author Affiliations
A. P. Popov, Univ. of Oulu (Finland)
A. V. Karmenyan, National Yang Ming Univ. (Taiwan)
A. V. Bykov, Univ. of Oulu (Finland)
E. V. Khaydukov, Institute on Laser and Information Technologies (Russian Federation)
A. V. Nechaev, Lomonosov Moscow Univ. of Fine Chemical Technology (Russian Federation)
O. A. Bibikova, Univ. of Oulu (Finland)
N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
V. Ya. Panchenko, Institute on Laser and Information Technologies (Russian Federation)
V. A. Semchishen, Institute on Laser and Information Technologies (Russian Federation)
V. N. Seminogov, Institute on Laser and Information Technologies (Russian Federation)
A. S. Akhmanov, Institute on Laser and Information Technologies (Russian Federation)
V. I. Sokolov, Institute on Laser and Information Technologies (Russian Federation)
M. T. Kinnunen, Univ. of Oulu (Finland)
V. V. Tuchin, Univ. of Oulu (Finland)
N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
A. V. Zvyagin, National Yang Ming Univ. (Taiwan)
Macquarie Univ. (Australia)


Published in SPIE Proceedings Vol. 8801:
Novel Biophotonic Techniques and Applications II
Alex Vitkin; Arjen Amelink, Editor(s)

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