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Proceedings Paper

Compact imaging system with single-photon sensitivity and picosecond time resolution for fluorescence-guided surgery with lifetime imaging capability
Author(s): F. Powolny; C. Bruschini; E. Dubikovskaya; E. Grigoriev; O. Michielin; K. Muehlethaler; J. O. Prior; D. Rimoldi; R. Sinisi; E. Charbon
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Paper Abstract

We present a single-photon camera for fluorescence imaging capable of providing both intensity and lifetime images, with an accuracy better than 100ps; the camera was fabricated in standard CMOS technology. As a first step towards the study of biologically relevant samples, it was used to characterize in-vitro cultured melanoma cells labeled with indocyanine green (ICG) and ICG conjugated with cyclic pentapeptide (RGDfK). The application field would be fluorescence-guided surgical oncology.

Paper Details

Date Published: 18 June 2013
PDF: 7 pages
Proc. SPIE 8798, Clinical and Biomedical Spectroscopy and Imaging III, 879806 (18 June 2013); doi: 10.1117/12.2032537
Show Author Affiliations
F. Powolny, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
C. Bruschini, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Ctr. Hospitalier Univ. Vaudois (Switzerland)
E. Dubikovskaya, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
E. Grigoriev, FORIMTECH S.A. (Switzerland)
O. Michielin, Ctr. Hospitalier Univ. Vaudois (Switzerland)
K. Muehlethaler, Ludwig Ctr. for Cancer Research, Univ. of Lausanne (Switzerland)
J. O. Prior, Ctr. Hospitalier Univ. Vaudois (Switzerland)
D. Rimoldi, Ludwig Ctr. for Cancer Research, Univ. of Lausanne (Switzerland)
R. Sinisi, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
E. Charbon, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Delft Univ.of Technology (Netherlands)


Published in SPIE Proceedings Vol. 8798:
Clinical and Biomedical Spectroscopy and Imaging III
Volker Deckert; Nirmala Ramanujam, Editor(s)

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