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Proceedings Paper

Adaptive focus for deep tissue using diffuse backscatter
Author(s): Jeremy Kress; Kambiz Pourrezaei
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Paper Abstract

A system integrating high density diffuse optical imaging with adaptive optics using MEMS for deep tissue interaction is presented. In this system, a laser source is scanned over a high density fiber bundle using Digital Micromirror Device (DMD) and channeled to a tissue phantom. Backscatter is then collected from the tissue phantom by a high density fiber array of different fiber type and channeled to CMOS sensor for image acquisition. Intensity focus is directly verified using a second CMOS sensor which measures intensity transmitted though the tissue phantom. A set of training patterns are displayed on the DMD and backscatter is numerically fit to the transmission intensity. After the training patterns are displayed, adaptive focus is performed using only the backscatter and fitting functions. Additionally, tissue reconstruction and prediction of interference focusing by photoacoustic and optical tomographic methods is discussed. Finally, potential NIR applications such as in-vivo adaptive neural photostimulation and cancer targeting are discussed.

Paper Details

Date Published: 26 February 2014
PDF: 14 pages
Proc. SPIE 8941, Optical Interactions with Tissue and Cells XXV; and Terahertz for Biomedical Applications, 89410P (26 February 2014); doi: 10.1117/12.2032525
Show Author Affiliations
Jeremy Kress, Drexel Univ. (United States)
Kambiz Pourrezaei, Drexel Univ. (United States)


Published in SPIE Proceedings Vol. 8941:
Optical Interactions with Tissue and Cells XXV; and Terahertz for Biomedical Applications
E. Duco Jansen; Gerald J. Wilmink; Bennett L. Ibey; Robert J. Thomas, Editor(s)

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