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Proceedings Paper

Characterization of the bruise healing process using pulsed photothermal radiometry
Author(s): Luka Vidovič; Matija Milanič; Lise L. Randeberg; Boris Majaron
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Paper Abstract

An analytical model of mass diffusion and biochemical transformation kinetics in bruise development and healing process was recently developed in order to simulate bruised skin color at various time points and enable objective determination of the time of injury. However, parameters of the model were not determined directly. Instead, biologically plausable values were applied in prior analyses. Pulsed photothermal radiometry (PPTR) allows noninvasive determination of the laser-induced temperature depth profile in human skin. We have applied this technique to characterize dynamics of extravasated hemoglobin concentration profile evolution. By applying Monte Carlo simulation of laser energy deposition and simulation of PPTR signal, a more exact comparison with measured temperature profiles is possible. We show that PPTR depth profiling can be used to derive rather accurate estimates of the hemoglobin mass diffusivity, hemoglobin degradation time, as well as approximate skin geometry. This enables assessment of the bruise healing dynamics and could offer a valuable addition to existing bruise age determination techniques.

Paper Details

Date Published: 18 June 2013
PDF: 10 pages
Proc. SPIE 8801, Novel Biophotonic Techniques and Applications II, 880104 (18 June 2013); doi: 10.1117/12.2032490
Show Author Affiliations
Luka Vidovič, Jožef Stefan Institute (Slovenia)
Matija Milanič, Jožef Stefan Institute (Slovenia)
Lise L. Randeberg, Norwegian Univ. of Science and Technology (Norway)
Boris Majaron, Jožef Stefan Institute (Slovenia)

Published in SPIE Proceedings Vol. 8801:
Novel Biophotonic Techniques and Applications II
Alex Vitkin; Arjen Amelink, Editor(s)

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