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Proceedings Paper

Visualizing a cytostatic drug and probing apoptosis of cancer cells
Author(s): Verena Richter; Petra Weber; Michael Wagner; Sarah Schickinger; Thomas Bruns; Herbert Schneckenburger
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Paper Abstract

The uptake and intracellular distribution of the cytostatic drug doxorubicin is visualized in 2D and 3D systems of human breast cancer cells and fibroblasts by fluorescence microscopy and spectroscopy. Fluorescence lifetime imaging (FLIM) and scattering experiments with high angular resolution are suggested to probe apoptotic reactions. A light scattering microscope as well as a light sheet module for 3D fluorescence microscopy have been developed and are used for this purpose.

Paper Details

Date Published: 18 June 2013
PDF: 5 pages
Proc. SPIE 8798, Clinical and Biomedical Spectroscopy and Imaging III, 879804 (18 June 2013); doi: 10.1117/12.2032461
Show Author Affiliations
Verena Richter, Hochschule Aalen (Germany)
Petra Weber, Hochschule Aalen (Germany)
Michael Wagner, Hochschule Aalen (Germany)
Sarah Schickinger, Hochschule Aalen (Germany)
Thomas Bruns, Hochschule Aalen (Germany)
Herbert Schneckenburger, Hochschule Aalen (Germany)

Published in SPIE Proceedings Vol. 8798:
Clinical and Biomedical Spectroscopy and Imaging III
Volker Deckert; Nirmala Ramanujam, Editor(s)

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