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Proceedings Paper

Finite element simulation of the gating mechanism of mechanosensitive ion channels
Author(s): Navid Bavi; Qinghua Qin; Boris Martinac
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Paper Abstract

In order to eliminate limitations of existing experimental or computational methods (such as patch-clamp technique or molecular dynamic analysis) a finite element (FE) model for multi length-scale and time-scale investigation on the gating mechanism of mechanosensitive (MS) ion channels has been established. Gating force value (from typical patch clamping values) needed to activate Prokaryotic MS ion channels was applied as tensional force to the FE model of the lipid bilayer. Making use of the FE results, we have discussed the effects of the geometrical and the material properties of the Escherichia coli MscL mechanosensitive ion channel opening in relation to the membrane’s Young’s modulus (which will vary depending on the cell type or cholesterol density in an artificial membrane surrounding the MscL ion channel). The FE model has shown that when the cell membrane stiffens the required channel activation force increases considerably. This is in agreement with experimental results taken from the literature. In addition, the present study quantifies the relationship between the membrane stress distribution around a ‘hole’ for modeling purposes and the stress concentration in the place transmembrane proteins attached to the hole by applying an appropriate mesh refinement as well as well defining contact condition in these areas.

Paper Details

Date Published: 9 August 2013
PDF: 7 pages
Proc. SPIE 8793, Fourth International Conference on Smart Materials and Nanotechnology in Engineering, 87931S (9 August 2013); doi: 10.1117/12.2030203
Show Author Affiliations
Navid Bavi, Australian National Univ. (Australia)
Victor Chang Cardiac Research Institute (Australia)
Qinghua Qin, Australian National Univ. (Australia)
Boris Martinac, Victor Chang Cardiac Research Institute (Australia)

Published in SPIE Proceedings Vol. 8793:
Fourth International Conference on Smart Materials and Nanotechnology in Engineering
Jayantha A. Epaarachchi; Alan Kin-tak Lau; Jinsong Leng, Editor(s)

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