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Proceedings Paper

A novel drug carrier based on functional modified nanofiber cellulose and the control release behavior
Author(s): Xiangning Shi; Yudong Zheng; Wei Zhang; Zeyu Zhang; Yunling Peng
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Paper Abstract

This study developed a novel drug carrier based on functional modified bacterial cellulose(BC) which was conjugated with Ibuprofen(IBU) by esterification. BC-Ibuprofen as the macro- molecular prodrugs and drug carrier used to improve the short half-life of the drug, and was able to control release through the hydrolysis of ester bond between the hydroxyl groups of BC with Ibuprofen under different condition. Fourier transform infrared analysis revealed that Ibuprofen had been successfully grafted onto the bacterial cellulose (BC). Thermal and morphological characterization indicated the formation of the BC-Ibuprofen system incompletely reacted maintained the bulk structure of the pristine material such as crystallinity, 3-dimentional network and so on. The drug release behaviours were affected by the ester bond hydrolysis as well as the microstructure characteristics of the modified nanofiber. The release of BC-IBU showed an apparent pH-dependent, fast in alkaline and acid solution but slow relatively in neutral. Such pH-responsiveness, in addition to its morphological characteristics, in this paper suggested a great potential of BC-IBU as a more effective, safe, and stable prodrug candidate.

Paper Details

Date Published: 9 August 2013
PDF: 6 pages
Proc. SPIE 8793, Fourth International Conference on Smart Materials and Nanotechnology in Engineering, 879304 (9 August 2013); doi: 10.1117/12.2027556
Show Author Affiliations
Xiangning Shi, Univ. of Science and Technology Beijing (China)
Yudong Zheng, Univ. of Science and Technology Beijing (China)
Wei Zhang, Univ. of Science and Technology Beijing (China)
Zeyu Zhang, Univ. of Science and Technology Beijing (China)
Yunling Peng, Univ. of Science and Technology Beijing (China)


Published in SPIE Proceedings Vol. 8793:
Fourth International Conference on Smart Materials and Nanotechnology in Engineering
Jayantha A. Epaarachchi; Alan Kin-tak Lau; Jinsong Leng, Editor(s)

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