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Proceedings Paper

Spectral investigations on binding of DNA-CTMA complex with tetrameric copper phthalocyanines
Author(s): Narayanan Venkat; Joy E. Haley; Rachel Swiger; Lei Zhu; Xiaoliang Wei; Fahima Ouchen; James G. Grote
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Paper Abstract

The binding of DNA-CTMA (Deoxyribonucleic acid-cetyltrimethylammonium) complex with two tetrameric Copper Phthalocyanine (CuPc) systems, substituted with carboxylic acid (CuPc-COOH) and derivatized further as an imidazolium salt (CuPc-COOR), was investigated in dimethylsulfoxide (DMSO) solutions using UV/Visible Spectroscopy. Absorbance changes at 685 nm (Q band of the CuPc) were monitored as a function of DNA-CTMA added to the dye solution and stock concentrations of DNA-CTMA in DMSO were varied to facilitate observation of the full binding process. Our findings indicated that while binding with DNA-CTMA was more well-defined in the case of CuPc-COOH, the binding profile of the CuPc-COOR showed initial growth followed by decay in its Q-band absorbance which was indicative of a more complex binding mechanism involving the dye and DNA-CTMA. Preliminary findings from photophysical studies involving the CuPc tetramers and DNA-CTMA are also discussed in this paper.

Paper Details

Date Published: 8 October 2013
PDF: 10 pages
Proc. SPIE 8817, Nanobiosystems: Processing, Characterization, and Applications VI, 88170E (8 October 2013); doi: 10.1117/12.2027207
Show Author Affiliations
Narayanan Venkat, Air Force Research Lab. (United States)
Univ. of Dayton Research Institute (United States)
Joy E. Haley, Air Force Research Lab. (United States)
Rachel Swiger, Air Force Research Lab. (United States)
Southwestern Ohio Council for Higher Education (United States)
Lei Zhu, Case Western Reserve Univ. (United States)
Xiaoliang Wei, Case Western Reserve Univ. (United States)
Fahima Ouchen, Air Force Research Lab. (United States)
Univ. of Dayton Research Institute (United States)
James G. Grote, Air Force Research Lab. (United States)


Published in SPIE Proceedings Vol. 8817:
Nanobiosystems: Processing, Characterization, and Applications VI
Norihisa Kobayashi; Fahima Ouchen; Ileana Rau, Editor(s)

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