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Proceedings Paper

Nano-engineered titanium for enhanced bone therapy
Author(s): Karan Gulati; Gerald J. Atkins; David M. Findlay; Dusan Losic
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Paper Abstract

Current treatment of a number of orthopaedic conditions, for example fractures, bone infection, joint replacement and bone cancers, could be improved if mechanical support could be combined with drug delivery. A very challenging example is that of infection following joint replacement, which is very difficult to treat, can require multiple surgeries and compromises both the implant and the patient’s wellbeing. An implant capable of providing appropriate biomechanics and releasing drugs/proteins locally might ensure improved healing of the traumatized bone. We propose fabrication of nanoengineered titanium bone implants using bioinert titanium wires in order to achieve this goal. Titanium in the form of flat foils and wires were modified by fabrication of titania nanotubes (TNTs), which are hollow self-ordered cylindrical tubes capable of accommodating substantial drug amounts and releasing them locally. To further control the release of drug to over a period of months, a thin layer of biodegradable polymer PLGA poly(lactic-coglycolic acid) was coated onto the drug loaded TNTs. This delayed release of drug and additionally the polymer enhanced bone cell adhesion and proliferation.

Paper Details

Date Published: 11 September 2013
PDF: 6 pages
Proc. SPIE 8812, Biosensing and Nanomedicine VI, 88120C (11 September 2013); doi: 10.1117/12.2027151
Show Author Affiliations
Karan Gulati, The Univ. of Adelaide (Australia)
Gerald J. Atkins, The Univ. of Adelaide (Australia)
David M. Findlay, The Univ. of Adelaide (Australia)
Dusan Losic, The Univ. of Adelaide (Australia)

Published in SPIE Proceedings Vol. 8812:
Biosensing and Nanomedicine VI
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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