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Proceedings Paper

Ultrasensitive biomolecular assays with amplifying nanowire FET biosensors
Author(s): Chi On Chui; Kyeong-Sik Shin; Yufei Mao
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Paper Abstract

In this paper, we review our recent development and validation of the ultrasensitive electronic biomolecular assays enabled by our novel amplifying nanowire field-effect transistor (nwFET) biosensors. Our semiconductor nwFET biosensor platform technology performs extreme proximity signal amplification in the electrical domain that requires neither labeling nor enzymes nor optics. We have designed and fabricated the biomolecular assay prototypes and developed the corresponding analytical procedures. We have also confirmed their analytical performance in quantitating key protein biomarker in human serum, demonstrating an ultralow limit of detection and concurrently high output current level for the first time.

Paper Details

Date Published: 19 September 2013
PDF: 6 pages
Proc. SPIE 8820, Nanoepitaxy: Materials and Devices V, 88200S (19 September 2013); doi: 10.1117/12.2026914
Show Author Affiliations
Chi On Chui, Univ. of California, Los Angeles (United States)
Kyeong-Sik Shin, Univ. of California, Los Angeles (United States)
Yufei Mao, Univ. of California, Los Angeles (United States)

Published in SPIE Proceedings Vol. 8820:
Nanoepitaxy: Materials and Devices V
Nobuhiko P. Kobayashi; A. Alec Talin; Albert V. Davydov; M. Saif Islam, Editor(s)

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