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Proceedings Paper

Single molecule sensing with carbon nanotube devices
Author(s): Yongki Choi; Patrick C. Sims; Tivoli J. Olsen; Mariam Iftikhar; Brad L. Corso; O. Tolga Gul; Gregory A. Weiss; Philip G. Collins
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Paper Abstract

Nanoscale electronic devices like field-effect transistors have long promised to provide sensitive, label-free detection of biomolecules. In particular, single-walled carbon nanotubes have the requisite sensitivity to detect single molecule events and sufficient bandwidth to directly monitor single molecule dynamics in real time. Recent measurements have demonstrated this premise by monitoring the dynamic, single-molecule processivity of three different enzymes: lysozyme, protein Kinase A, and the Klenow fragment of DNA polymerase I. In each case, recordings resolved detailed trajectories of tens of thousands of individual chemical events and provided excellent statistics for single-molecule events. This electronic technique has a temporal resolution approaching 1 microsecond, which provides a new window for observing brief, intermediate transition states. In addition, the devices are indefinitely stable, so that the same molecule can be observed for minutes and hours. The extended recordings provide new insights into rare events like transitions to chemically-inactive conformations.

Paper Details

Date Published: 24 September 2013
PDF: 9 pages
Proc. SPIE 8814, Carbon Nanotubes, Graphene, and Associated Devices VI, 88140Q (24 September 2013); doi: 10.1117/12.2025661
Show Author Affiliations
Yongki Choi, Univ. of California, Irvine (United States)
Patrick C. Sims, Univ. of California, Irvine (United States)
Tivoli J. Olsen, Univ. of California, Irvine (United States)
Mariam Iftikhar, Univ. of California, Irvine (United States)
Brad L. Corso, Univ. of California, Irvine (United States)
O. Tolga Gul, Univ. of California, Irvine (United States)
Gregory A. Weiss, Univ. of California, Irvine (United States)
Philip G. Collins, Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 8814:
Carbon Nanotubes, Graphene, and Associated Devices VI
Didier Pribat; Young Hee Lee; Manijeh Razeghi; Seunghyun Baik, Editor(s)

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