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Proceedings Paper

A biosensor of high-density lipoprotein of human serum on a liquid crystal and polymer composite film
Author(s): Yi-Hsin Lin; Kai-Han Chang; Wei-Lin Chu; Yu-Shih Tsou; Li-Ching Wu; Chien-Feng Li
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Paper Abstract

A biosensor for the concentration of high-density lipoprotein (HDL) in human serum on a liquid crystal and polymer composite film (LCPCF) is demonstrated. The sensing mechanism is based on a polar-polar interaction between orientation of LC directors and HDL in human serum. The concentration of polar HDL in human serum affects the orientations of LC directors at the interface between LCPCF and the human serum. In addition, the surface free energy of LCPCF changes with the applied voltage due to the electrically tunable orientations of LC directors anchored among the polymer grains of LCPCF. As a result, the droplet motion of human serum on LCPCF under applied voltages can sense the concentration of HDL in human serum.

Paper Details

Date Published: 1 October 2013
PDF: 6 pages
Proc. SPIE 8828, Liquid Crystals XVII, 88280I (1 October 2013); doi: 10.1117/12.2025382
Show Author Affiliations
Yi-Hsin Lin, National Chiao Tung Univ. (Taiwan)
Kai-Han Chang, National Chiao Tung Univ. (Taiwan)
Wei-Lin Chu, National Chiao Tung Univ. (Taiwan)
Yu-Shih Tsou, National Chiao Tung Univ. (Taiwan)
Li-Ching Wu, Chimei Medical Ctr. (Taiwan)
Chien-Feng Li, Chimei Medical Ctr. (Taiwan)


Published in SPIE Proceedings Vol. 8828:
Liquid Crystals XVII
Iam Choon Khoo, Editor(s)

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