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Proceedings Paper

Enhancing molecular logic through modulation of temporal and spatial constraints with quantum dot-based systems that use fluorescent (Förster) resonance energy transfer
Author(s): Jonathan C. Claussen; W. Russ Algar; Niko Hildebrandt; Kimihiro Susumu; Mario G. Ancona; Igor L. Medintz
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Paper Abstract

Luminescent semiconductor nanocrystals or quantum dots (QDs) contain favorable photonic properties (e.g., resistance to photobleaching, size-tunable PL, and large effective Stokes shifts) that make them well-suited for fluorescence (Förster) resonance energy transfer (FRET) based applications including monitoring proteolytic activity, elucidating the effects of nanoparticles-mediated drug delivery, and analyzing the spatial and temporal dynamics of cellular biochemical processes. Herein, we demonstrate how unique considerations of temporal and spatial constraints can be used in conjunction with QD-FRET systems to open up new avenues of scientific discovery in information processing and molecular logic circuitry. For example, by conjugating both long lifetime luminescent terbium(III) complexes (Tb) and fluorescent dyes (A647) to a single QD, we can create multiple FRET lanes that change temporally as the QD acts as both an acceptor and donor at distinct time intervals. Such temporal FRET modulation creates multi-step FRET cascades that produce a wealth of unique photoluminescence (PL) spectra that are well-suited for the construction of a photonic alphabet and photonic logic circuits. These research advances in bio-based molecular logic open the door to future applications including multiplexed biosensing and drug delivery for disease diagnostics and treatment.

Paper Details

Date Published: 1 October 2013
PDF: 9 pages
Proc. SPIE 8817, Nanobiosystems: Processing, Characterization, and Applications VI, 88170O (1 October 2013); doi: 10.1117/12.2024287
Show Author Affiliations
Jonathan C. Claussen, U.S. Naval Research Lab. (United States)
George Mason Univ. (United States)
W. Russ Algar, The Univ. of British Columbia (Canada)
Niko Hildebrandt, Institut d'Électronique Fondamentale, Univ. Paris Sud (France)
Kimihiro Susumu, U.S. Naval Research Lab. (United States)
Sotera Defense Solutions (United States)
Mario G. Ancona, U.S. Naval Research Lab. (United States)
Igor L. Medintz, U.S. Naval Research Lab. (United States)


Published in SPIE Proceedings Vol. 8817:
Nanobiosystems: Processing, Characterization, and Applications VI
Norihisa Kobayashi; Fahima Ouchen; Ileana Rau, Editor(s)

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