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Proceedings Paper

The interaction of the carbon nanoparticles with human cell plasma membrane
Author(s): M. Overchuk; S. Prylutska; Rostyslav Bilyy; Yu. Prylutsky; U. Ritter
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Paper Abstract

The study of carbon nanostructures is a highly topical branch of bionanotechnology because of their potential application in biomedicine. Carbon nanotubes (CNTs) are known for their ability to kill tumor cells causing hyperthermia shock and can be used in photothermal therapy respectively. Also chemically modified CNTs can be used for drug delivery. The needle-like shape of CNTs allows them to penetrate into the cell plasma membrane without killing the cell. C60 fullerenes are regarded as valuable nanocarriers for different hydrophobic molecules as well as potential antiviral agents or photosensitizers. In our previous studies we have demonstrated that all types of carbon nanoparticles cause externalization of phosphatidylserine (PS) from the inner to the outer layer of the cell membrane in the small local patches (points of contact), leaving the other parts of plasma membrane PS-negative. In the current work there were studied the interactions of pristine C60 fullerenes and different types of CNTs with human blood cells (erythrocytes and Jurkat T-cells). We have shown, that carbon nanoparticles do not have any hemolytic effects, if judged by the dynamics of acidic hemolysis, although they are capable of permeabilizating the cells and facilitating the internalization of propidium iodide into the nuclei.

Paper Details

Date Published: 11 September 2013
PDF: 6 pages
Proc. SPIE 8812, Biosensing and Nanomedicine VI, 88120X (11 September 2013); doi: 10.1117/12.2023271
Show Author Affiliations
M. Overchuk, Ivan Franko National Univ. of Lviv (Ukraine)
S. Prylutska, Taras Shevchenko National. Univ. of Kiev (Ukraine)
Rostyslav Bilyy, Institute of Cell Biology (Ukraine)
Yu. Prylutsky, Taras Shevchenko National. Univ. of Kiev (Ukraine)
U. Ritter, Ilmenau Univ. of Technology (Germany)


Published in SPIE Proceedings Vol. 8812:
Biosensing and Nanomedicine VI
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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