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Proceedings Paper

Non-invasive continuous imaging of drug release from soy-based skin equivalent using wide-field interferometry
Author(s): Haniel Gabai; Maya Baranes-Zeevi; Meital Zilberman; Natan T. Shaked
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Paper Abstract

We propose an off-axis interferometric imaging system as a simple and unique modality for continuous, non-contact and non-invasive wide-field imaging and characterization of drug release from its polymeric device used in biomedicine. In contrast to the current gold-standard methods in this field, usually based on chromatographic and spectroscopic techniques, our method requires no user intervention during the experiment, and only one test-tube is prepared. We experimentally demonstrate imaging and characterization of drug release from soy-based protein matrix, used as skin equivalent for wound dressing with controlled anesthetic, Bupivacaine drug release. Our preliminary results demonstrate the high potential of our method as a simple and low-cost modality for wide-field imaging and characterization of drug release from drug delivery devices.

Paper Details

Date Published: 23 May 2013
PDF: 6 pages
Proc. SPIE 8792, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials, 879215 (23 May 2013); doi: 10.1117/12.2020485
Show Author Affiliations
Haniel Gabai, Tel Aviv Univ. (Israel)
Maya Baranes-Zeevi, Tel Aviv Univ. (Israel)
Meital Zilberman, Tel Aviv Univ. (Israel)
Natan T. Shaked, Tel Aviv Univ. (Israel)


Published in SPIE Proceedings Vol. 8792:
Optical Methods for Inspection, Characterization, and Imaging of Biomaterials
Pietro Ferraro; Monika Ritsch-Marte; Simonetta Grilli; David Stifter, Editor(s)

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