Share Email Print
cover

Proceedings Paper

Locally applied simvastatin improves fracture healing at late period in osteoporotic rat
Author(s): Faming Tian; Liu Zhang; Yuchuan Kang; Junshan Zhang; Jiao Ao; Fang Yang
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

effect of simvastatin locally applied from a bioactive polymer coating of implants on osteoporotic fracture healing at late period. Methods:Femur fracture model was established on normal or osteotoporotic mature female SD rats, intramedullary stabilization was achieved with uncoated titanium Kirschnerwires in normal rats(group A),with polymer-only coated vs. polymer plus simvastatin coated titanium Kirschner wires in osteoporotic rats(group B and C, respectively).Femurs were harvested after 12 weeks, and underwent radiographic and histologic analysis, as well as immunohistochemical evaluation for BMP-2 expression. Results:Radiographic results demonstrated progressed callus in the simvastatin-treated groups compared to the uncoated group.The histologic analysis revealed a significantly processed callus with irregular-shaped newly formed bone trabeculae in simvastatin-treated group. Immunohistochemical evaluation showed markedly higher expression levels of B:MP-2 in simvastatin-treated group.Conclusions: The present study revealed a improved fracture healing under local application of simvastatin in osteoporotic rat,which might partially from upregulation of the B:MP-2 expression at fractured site.

Paper Details

Date Published: 19 March 2013
PDF: 6 pages
Proc. SPIE 8762, PIAGENG 2013: Intelligent Information, Control, and Communication Technology for Agricultural Engineering, 87621S (19 March 2013); doi: 10.1117/12.2019682
Show Author Affiliations
Faming Tian, Hebei United Univ. (China)
Liu Zhang, Affiliated Hospital of Hebei United Univ. (China)
Yuchuan Kang, Affiliated Hospital of Hebei United Univ. (China)
Junshan Zhang, Affiliated Hospital of Hebei United Univ. (China)
Jiao Ao, Affiliated Hospital of Hebei United Univ. (China)
Fang Yang, Hebei United Univ. (China)


Published in SPIE Proceedings Vol. 8762:
PIAGENG 2013: Intelligent Information, Control, and Communication Technology for Agricultural Engineering
Honghua Tan, Editor(s)

© SPIE. Terms of Use
Back to Top