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Proceedings Paper

Aptamer-conjugated gold nanorod for photothermal ablation of EGFR-overexpressed epithelial cancer
Author(s): Jihye Choi; Yeonji Park; Eun Bi Choi; Hyun-Ouk Kim; Yoochan Hong; Sung-Ho Ryu; Jung Hwan Lee; Jin-Suck Suh; Jaemoon Yang; Yong-Min Huh; Seungjoo Haam
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Paper Abstract

Biomarker-specific photothermal nanoparticles that can efficiently sense the markers, which are overexpressed in distinguished adenocarcinomas, has attracted much interest in an aspect of efficacy increase of cancer treatment. In this study, we demonstrated a promising prospect of smart photothermal therapy agent employing anti-epidermal growth factor receptor aptamer (AptEGFR)-conjugated polyethylene glycol (PEG)layted gold nanorods (AptEGFR-PGNRs). The cetyltrimethylammonium bromide bilayer on GNRs was replaced with heterobifunctional polyethylene glycol (COOHPEG- SH) not only to serve as a biocompatible stabilizer and but also to conjugate AptEGFR. Subsequently, to direct photothermal therapy agent toward epithelial cancer cells, the carboxylated PEGylated GNRs (PGNRs) were further functionalized with AptEGFR using carbodiimide chemistry. And then, to assess the potential as biomarker-specific photothermal therapy agent of synthesized AptEGFR-PGNRs, the optical properties, biocompatibility, colloidal stability, binding affinity and epicellial cancer cell killing efficacy in vitro/in vivo under NIR laser irradiation were investigated. As a results, AptEGFR-PGNRs exhibit excellent tumor targeting ability and feasibility of effective photothermal ablation cancer therapy.

Paper Details

Date Published: 20 May 2013
PDF: 9 pages
Proc. SPIE 8879, Nano-Bio Sensing, Imaging, and Spectroscopy, 88790S (20 May 2013); doi: 10.1117/12.2018719
Show Author Affiliations
Jihye Choi, Yonsei Univ. (Korea, Republic of)
Yeonji Park, Yonsei Univ. (Korea, Republic of)
Eun Bi Choi, Yonsei Univ. (Korea, Republic of)
Hyun-Ouk Kim, Yonsei Univ. (Korea, Republic of)
Yoochan Hong, Yonsei Univ. (Korea, Republic of)
Sung-Ho Ryu, Pohang Univ. of Science and Technology (Korea, Republic of)
Jung Hwan Lee, Pohang Univ. of Science and Technology (Korea, Republic of)
Jin-Suck Suh, Yonsei Univ. (Korea, Republic of)
Jaemoon Yang, Yonsei Univ. (Korea, Republic of)
Yong-Min Huh, Yonsei Univ. (Korea, Republic of)
Seungjoo Haam, Yonsei Univ. (Korea, Republic of)

Published in SPIE Proceedings Vol. 8879:
Nano-Bio Sensing, Imaging, and Spectroscopy
Shin Won Kang; Seung-Han Park; Luke P. Lee; Ki-Bong Song; Yo Han Choi, Editor(s)

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