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Proceedings Paper

Probing multi-scale self-similarity of tissue structures using light scattering spectroscopy: prospects in pre-cancer detection
Author(s): Subhasri Chatterjee; Nandan K. Das; Satish Kumar; Sonali Mohapatra; Asima Pradhan; Prasanta K. Panigrahi; Nirmalya Ghosh
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Paper Abstract

Multi-resolution analysis on the spatial refractive index inhomogeneities in the connective tissue regions of human cervix reveals clear signature of multifractality. We have thus developed an inverse analysis strategy for extraction and quantification of the multifractality of spatial refractive index fluctuations from the recorded light scattering signal. The method is based on Fourier domain pre-processing of light scattering data using Born approximation, and its subsequent analysis through Multifractal Detrended Fluctuation Analysis model. The method has been validated on several mono- and multi-fractal scattering objects whose self-similar properties are user controlled and known a-priori. Following successful validation, this approach has initially been explored for differentiating between different grades of precancerous human cervical tissues.

Paper Details

Date Published: 26 February 2013
PDF: 9 pages
Proc. SPIE 8699, Saratov Fall Meeting 2012: Optical Technologies in Biophysics and Medicine XIV; and Laser Physics and Photonics XIV, 86990D (26 February 2013); doi: 10.1117/12.2016849
Show Author Affiliations
Subhasri Chatterjee, Indian Institute of Science Education and Research Kolkata (India)
Nandan K. Das, Indian Institute of Science Education and Research Kolkata (India)
Satish Kumar, The Univ. of Texas at Arlington (United States)
Sonali Mohapatra, Indian Institute of Science Education and Research Kolkata (India)
Asima Pradhan, Indian Institute of Technology Kanpur (India)
Prasanta K. Panigrahi, Indian Institute of Science Education and Research Kolkata (India)
Nirmalya Ghosh, Indian Institute of Science Education and Research Kolkata (India)


Published in SPIE Proceedings Vol. 8699:
Saratov Fall Meeting 2012: Optical Technologies in Biophysics and Medicine XIV; and Laser Physics and Photonics XIV
Valery V. Tuchin; Elina A. Genina; Vladimir L. Derbov; Igor V. Meglinski, Editor(s)

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