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Proceedings Paper

Detection of small trace molecules in human and animal exhalation by tunable diode lasers for applications in biochemistry and medical diagnostics
Author(s): Eugene V. Stepanov; Andrian I. Kouznetsov; Pavel V. Zyrianov; Vladimir A. Skrupskii; Yurii A. Shulagin; Marina E. Galagan
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Paper Abstract

Tunable diode laser spectroscopy (TDLS) is proposed for content measurements of trace gases like CO, CO2, NH3, CH4, NO, NO2 in human and animal exhalation. High sensitivity and wide dynamic range of the method ensure fast detection of these gases at ppb level and within the accuracy better than 10%. One-expiration sample is enough to reach these parameters. There is no need for any preliminary preparations of tested samples. Some pairs of the gases, for instance, CO and CO2, NH3 and CO2 and CO and N2O, can be measured simultaneously by one laser providing complex studies. The high sensitive gas analysis could provide necessary background to the noninvasive diagnostics in a wide variety of medical problems. Perspectives of the TDLS methods in application to medicine diagnostics are demonstrated by the first results of exhalation tests.

Paper Details

Date Published: 10 February 1995
PDF: 11 pages
Proc. SPIE 2331, Medical Sensors II and Fiber Optic Sensors, (10 February 1995); doi: 10.1117/12.201243
Show Author Affiliations
Eugene V. Stepanov, Institute of General Physics (Russia)
Andrian I. Kouznetsov, Engelharb Sensor Technologies (United States)
Pavel V. Zyrianov, Institute of General Physics (Russia)
Vladimir A. Skrupskii, Institute of Oceanology (Russia)
Yurii A. Shulagin, Institute of Oceanology (Russia)
Marina E. Galagan, Institute of Chemical Physics (Russia)


Published in SPIE Proceedings Vol. 2331:
Medical Sensors II and Fiber Optic Sensors
Anna Maria Verga Scheggi; Francesco Baldini; Pierre R. Coulet; Otto S. Wolfbeis, Editor(s)

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