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Proceedings Paper

Application of phase shift ring down spectroscopy to microcavities for biosensing
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Paper Abstract

Phase shift ring down measurement approach (PS-CRDS) is used to develop a real time biosensor which can simultaneously track the quality factor Q and the resonant wavelength λr of microcavities as a function of the biodetection event. We have developed a mathematical model to predict the binding event with high accuracy by utilizing the information from these two physical parameters (Q and λr). Experiments are also conducted to validate the model. Hence, PS-CRDS biosensor in conjunction with the estimation model, will pave the way for highly sensitive measurements of biological entities/processes ranging from micron to nano scale.

Paper Details

Date Published: 19 February 2013
PDF: 6 pages
Proc. SPIE 8594, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications X, 859401 (19 February 2013); doi: 10.1117/12.2011779
Show Author Affiliations
M. Imran Cheema, McGill Univ. (Canada)
Usman A. Khan, Tufts Univ. (United States)
Andrea M. Armani, Univ. of Southern California (United States)
Andrew G. Kirk, McGill Univ. (Canada)

Published in SPIE Proceedings Vol. 8594:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications X
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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