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Proceedings Paper

Enhanced magnetic resonance contrast of iron oxide nanoparticles embedded in a porous silicon nanoparticle host
Author(s): Joseph Kinsella; Shalini Ananda; Jennifer Andrew; Joel Grondek; Miao-Ping Chien; Miriam Scandeng; Nathan Gianneschi; Erkki Ruoslahti; Michael Sailor
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Paper Abstract

In this report, we prepared a porous Si nanoparticle with a pore morphology that facilitates the proximal loading and alignment of magnetite nanoparticles. We characterized the composite materials using superconducting quantum interference device magnetometry, dynamic light scattering, transmission electron microscopy, and MRI. The in vitro cytotoxicity of the composite materials was tested using cell viability assays on human liver cancer cells and rat hepatocytes. An in vivo analysis using a hepatocellular carcinoma (HCC) Sprague Dawley rat model was used to determine the biodistribution properties of the material, while naïve Sprague Dawley rats were used to determine the pharmocokinetic properties of the nanomaterials. The composite material reported here demonstrates an injectable nanomaterial that exploits the dipolar coupling of superparamagnetic nanoparticles trapped within a secondary inorganic matrix to yield significantly enhanced MRI contrast. This preparation successfully avoids agglomeration issues that plague larger ferromagnetic systems. A Fe3O4:pSi composite formulation consisting of 25% by mass Fe3O4 yields an maximal T2* value of 556 mM Fe−1 s−1. No cellular (HepG2 or rat hepatocyte cells) or in vivo (rat) toxicity was observed with the formulation, which degrades and is eliminated after 4–8 h in vivo. The ability to tailor the magnetic properties of such materials may be useful for in vivo imaging, magnetic hyperthermia, or drug-delivery applications.

Paper Details

Date Published: 19 February 2013
PDF: 8 pages
Proc. SPIE 8594, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications X, 859409 (19 February 2013); doi: 10.1117/12.2009784
Show Author Affiliations
Joseph Kinsella, McGill Univ. (Canada)
Shalini Ananda, Univ. of California, San Diego (United States)
Jennifer Andrew, Univ. of Florida (United States)
Joel Grondek, Univ. of California, San Diego (United States)
Miao-Ping Chien, Univ. of California, San Diego (United States)
Miriam Scandeng, Univ. of California, San Diego (United States)
Nathan Gianneschi, Univ. of California, San Diego (United States)
Erkki Ruoslahti, Sanford Burnham Medical Research Institute (United States)
Michael Sailor, Univ. of California, San Diego (United States)
Univ. of Florida (United States)

Published in SPIE Proceedings Vol. 8594:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications X
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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