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Proceedings Paper

Highly efficient multifunctional MnSe/ZnSeS quantum dots for biomedical applications
Author(s): Leisha M. Armijo; Brian A. Akins; John B. Plumley; Antonio C. Rivera; Nathan J. Withers; Nathaniel C. Cook; Gennady A. Smolyakov; Dale L. Huber; Hugh D. C. Smyth; Marek Osiński
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Paper Abstract

Colloidal quantum dots (QDs) are of interest for a variety of biomedical applications, including bioimaging, drug targeting, and photodynamic therapy. However, a significant limitation is that highly efficient photoluminescent QDs available commercially contain cadmium. Recent research has focused on cadmium-free QDs, which are anticipated to exhibit significantly lower cytotoxicity. Previous work has focused on InP and ZnO as alternative semiconductor materials for QDs. However, these nanoparticles have been shown to be cytotoxic. Recently, we have synthesized high quantum efficiency (exceeding 90%), color tunable MnSe/ZnSeS nanoparticles, as potentially attractive QDs for biomedical applications. Additionally, the manganese imparts magnetic properties on the QDs, which are important for magnetic field-guided transport, hyperthermia, and potentially magnetic resonance imaging (MRI). The QDs can be further biofunctionalized via conjugation to a ligand or a biomarker of disease, allowing combination of drug delivery with visual verification and colocalization due to the color tunability of the QDs.

Paper Details

Date Published: 13 March 2013
PDF: 7 pages
Proc. SPIE 8595, Colloidal Nanocrystals for Biomedical Applications VIII, 859517 (13 March 2013); doi: 10.1117/12.2009563
Show Author Affiliations
Leisha M. Armijo, The Univ. of New Mexico (United States)
Brian A. Akins, The Univ. of New Mexico (United States)
John B. Plumley, The Univ. of New Mexico (United States)
Antonio C. Rivera, The Univ. of New Mexico (United States)
Nathan J. Withers, The Univ. of New Mexico (United States)
Nathaniel C. Cook, The Univ. of New Mexico (United States)
Gennady A. Smolyakov, The Univ. of New Mexico (United States)
Dale L. Huber, Sandia National Labs. (United States)
Hugh D. C. Smyth, The Univ. of Texas at Austin (United States)
Marek Osiński, The Univ. of New Mexico (United States)


Published in SPIE Proceedings Vol. 8595:
Colloidal Nanocrystals for Biomedical Applications VIII
Wolfgang J. Parak; Marek Osinski; Kenji Yamamoto, Editor(s)

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