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Proceedings Paper

Clinical feasibility study of combined opto-acoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors
Author(s): Jason Zalev; Bryan Clingman; Remie J. Smith; Don Herzog; Tom Miller; A. Thomas Stavros; Sergey Ermilov; André Conjusteau; Dmitri Tsyboulski; Alexander A. Oraevsky; Kenneth Kist; N. Carol Dornbluth; Pamela Otto
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Paper Abstract

We report on findings from the clinical feasibility study of the ImagioTM. Breast Imaging System, which acquires two-dimensional opto-acoustic (OA) images co-registered with conventional ultrasound using a specialized duplex hand-held probe. Dual-wavelength opto-acoustic technology is used to generate parametric maps based upon total hemoglobin and its oxygen saturation in breast tissues. This may provide functional diagnostic information pertaining to tumor metabolism and microvasculature, which is complementary to morphological information obtained with conventional gray-scale ultrasound. We present co-registered opto-acoustic and ultrasonic images of malignant and benign tumors from a recent clinical feasibility study. The clinical results illustrate that the technology may have the capability to improve the efficacy of breast tumor diagnosis. In doing so, it may have the potential to reduce biopsies and to characterize cancers that were not seen well with conventional gray-scale ultrasound alone.

Paper Details

Date Published: 4 March 2013
PDF: 9 pages
Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 858103 (4 March 2013); doi: 10.1117/12.2009112
Show Author Affiliations
Jason Zalev, Seno Medical Instruments (United States)
Bryan Clingman, Seno Medical Instruments (United States)
Remie J. Smith, Seno Medical Instruments (United States)
Don Herzog, Seno Medical Instruments (United States)
Tom Miller, Seno Medical Instruments (United States)
A. Thomas Stavros, Seno Medical Instruments (United States)
Sergey Ermilov, TomoWave Labs. Inc. (United States)
André Conjusteau, TomoWave Labs. Inc. (United States)
Dmitri Tsyboulski, TomoWave Labs. Inc. (United States)
Alexander A. Oraevsky, TomoWave Labs. Inc. (United States)
Kenneth Kist, Univ. of Texas Health Science Ctr. (United States)
N. Carol Dornbluth, Univ. of Texas Health Science Ctr. (United States)
Pamela Otto, Univ. of Texas Health Science Ctr. (United States)


Published in SPIE Proceedings Vol. 8581:
Photons Plus Ultrasound: Imaging and Sensing 2013
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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