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Ultrastructural evaluation of CaD2 mouse mammary carcinoma after photodynamic therapy with meso-tetra(hydroxyphenyl)porphyrin (m-THPP) or its corresponding chlorin (m-THPC)
Author(s): Qian Peng; Johan Moan; Jahn M. Nesland
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Paper Abstract

The ultrastructural changes that occurred in CaD2 mouse mammary carcinoma at 1, 24, and 96 h after photodynamic therapy (PDT) with meso-tetra(m-hydroxyphenyl)porphyrin (m- THPP, 5 mg/kg b.w.) or its corresponding chlorin (m-THPC, 1 mg/kg b.w.) were investigated. The destruction of the tumors occurred at a faster rate and was more severe by m-THPC-PDT than m-THPP-PDT, although the dose of m-THPC used was 5 times lower than that of m-THPP. The ultrastructral alterations of the tumors after PDT with m-THPP or m-THPC were qualitatively similar: direct damage to both microvasculature and neoplastic cells of the tumors.

Paper Details

Date Published: 1 February 1995
PDF: 11 pages
Proc. SPIE 2329, Optical and Imaging Techniques in Biomedicine, (1 February 1995); doi: 10.1117/12.200905
Show Author Affiliations
Qian Peng, Norwegian Radium Hospital (Norway)
Johan Moan, Norwegian Radium Hospital (Norway)
Jahn M. Nesland, Norwegian Radium Hospital (Norway)

Published in SPIE Proceedings Vol. 2329:
Optical and Imaging Techniques in Biomedicine
Hans-Jochen Foth; Aaron Lewis; Halina Podbielska; Michel Robert-Nicoud; Herbert Schneckenburger; Anthony J. Wilson, Editor(s)

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