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Proceedings Paper

Towards non-invasive in vivo measurements of nanoparticle concentrations using 3D optoacoustic tomography
Author(s): Dmitri Tsyboulski; Anton Liopo; Richard Su; Sergei Ermilov; Sergei Bachilo; R. Bruce Weisman; Alexander A. Oraevsky
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Paper Abstract

In this report, we demonstrate the feasibility of using optoacoustic tomography for deducing biodistributions of nanoparticles in animal models. The redistribution of single-walled carbon nanotubes (SWCNTs) was visualized in living mice. Nanoparticle concentrations in harvested organs were measured spectroscopically using the intrinsic optical absorption and fluorescence of SWCNTs. Observed increases in optoacoustic signal brightness in tissues were compared with increases in optical absorptivity coefficients caused by SWCNT accumulation. The methodology presented in this report paves the way for measuring concentrations of optically absorbing agents in small animals using optoacoustic tomography.

Paper Details

Date Published: 4 March 2013
PDF: 7 pages
Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85814V (4 March 2013); doi: 10.1117/12.2008897
Show Author Affiliations
Dmitri Tsyboulski, TomoWave Labs. Inc. (United States)
Anton Liopo, TomoWave Labs. Inc. (United States)
Richard Su, TomoWave Labs. Inc. (United States)
Sergei Ermilov, TomoWave Labs. Inc. (United States)
Sergei Bachilo, Rice Univ. (United States)
R. Bruce Weisman, Rice Univ. (United States)
Alexander A. Oraevsky, Rice Univ. (United States)

Published in SPIE Proceedings Vol. 8581:
Photons Plus Ultrasound: Imaging and Sensing 2013
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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