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Proceedings Paper

Targeting of systemically-delivered magnetic nanoparticle hyperthermia using a noninvasive, static, external magnetic field
Author(s): Grayson D. Zulauf; B. Stuart Trembly; Andrew J. Giustini; Brian R. Flint; Rendall R. Strawbridge; P. Jack Hoopes
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Paper Abstract

One of the greatest challenges of nanoparticle cancer therapy is the delivery of adequate numbers of nanoparticles to the tumor site. Iron oxide nanoparticles (IONPs) have many favorable qualities, including their nontoxic composition, the wide range of diameters in which they can be produced, the cell-specific cytotoxic heating that results from their absorption of energy from a nontoxic, external alternating magnetic field (AMF), and the wide variety of functional coatings that can be applied. Although IONPs can be delivered via an intra-tumoral injection to some tumors, the resulting tumor IONP distribution is generally inadequate; additionally, local tumor injections do not allow for the treatment of systemic or multifocal disease. Consequently, the ultimate success of nanoparticle based cancer therapy likely rests with successful systemic, tumor-targeted IONP delivery. In this study, we used a surface-based, bilateral, noninvasive static magnetic field gradient produced by neodymiumboron- iron magnets (80 T/m to 130 T/m in central plane between magnets), a rabbit ear model, and systemicallydelivered starch-coated 100 nm magnetic (iron oxide) nanoparticles to demonstrate a spatially-defined increase in the local tissue accumulation of IONPs. In this non-tumor model, the IONPs remained within the local vascular space. It is anticipated that this technique can be used to enhance IONP delivery significantly to the tumor parenchyma/cells.

Paper Details

Date Published: 26 February 2013
PDF: 9 pages
Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 85840C (26 February 2013); doi: 10.1117/12.2008816
Show Author Affiliations
Grayson D. Zulauf, Thayer School of Engineering at Dartmouth (United States)
B. Stuart Trembly, Thayer School of Engineering at Dartmouth (United States)
Andrew J. Giustini, Geisel School of Medicine (United States)
Brian R. Flint, Thayer School of Engineering at Dartmouth (United States)
Rendall R. Strawbridge, Geisel School of Medicine (United States)
P. Jack Hoopes, Geisel School of Medicine (United States)


Published in SPIE Proceedings Vol. 8584:
Energy-based Treatment of Tissue and Assessment VII
Thomas P. Ryan, Editor(s)

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