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Proceedings Paper

Biodistribution of antibody-targeted and non-targeted iron oxide nanoparticles in a breast cancer mouse model
Author(s): Jennifer A. Tate; Warren Kett; Christian NDong; Karl E. Griswold; P. Jack Hoopes
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Paper Abstract

Iron oxide nanoparticle (IONP) hyperthermia is a novel therapeutic strategy currently under consideration for the treatment of various cancer types. Systemic delivery of IONP followed by non-invasive activation via a local alternating magnetic field (AMF) results in site-specific energy deposition in the IONP-containing tumor. Targeting IONP to the tumor using an antibody or antibody fragment conjugated to the surface may enhance the intratumoral deposition of IONP and is currently being pursued by many nanoparticle researchers. This strategy, however, is subject to a variety of restrictions in the in vivo environment, where other aspects of IONP design will strongly influence the biodistribution. In these studies, various targeted IONP are compared to non-targeted controls. IONP were injected into BT-474 tumor-bearing NSG mice and tissues harvested 24hrs post-injection. Results indicate no significant difference between the various targeted IONP and the non-targeted controls, suggesting the IONP were prohibitively-sized to incur tumor penetration. Additional strategies are currently being pursued in conjuncture with targeted particles to increase the intratumoral deposition.

Paper Details

Date Published: 26 February 2013
PDF: 8 pages
Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 85840G (26 February 2013); doi: 10.1117/12.2008814
Show Author Affiliations
Jennifer A. Tate, Thayer School of Engineering at Dartmouth (United States)
Warren Kett, Thayer School of Engineering at Dartmouth (United States)
Christian NDong, Thayer School of Engineering at Dartmouth (United States)
Karl E. Griswold, Thayer School of Engineering at Dartmouth (United States)
P. Jack Hoopes, Dartmouth Medical School (United States)

Published in SPIE Proceedings Vol. 8584:
Energy-based Treatment of Tissue and Assessment VII
Thomas P. Ryan, Editor(s)

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