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Proceedings Paper

Multi-spectral analysis of animal tissues in the second NIR window based on endogenous chromophores
Author(s): Qian Cao; Steven T. Wang; Natalia G. Zhegalova; Walter J. Akers; Mikhail Y. Berezin
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Paper Abstract

To minimize the problem with scattering in deep tissues while increasing the penetration depth, we explored the feasibility of imaging in the previously unexplored extended NIR (exNIR) spectral region at 900 - 1400 nm with endogenous chromophores. This region, also known as second NIR window, is weakly dominated by absorption of water and lipids and free from other endogenous chromophores, with virtually no autofluorescence. To demonstrate the applicability of the exNIR in bioimaging, we analyzed optical properties of individual components and animal organs using InGaAs spectrophotometer and a multispectral InGaAs scanning imager featuring in transmission geometry.

Paper Details

Date Published: 22 February 2013
PDF: 8 pages
Proc. SPIE 8587, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI, 85870V (22 February 2013); doi: 10.1117/12.2008786
Show Author Affiliations
Qian Cao, Washington Univ. School of Medicine in St. Louis (United States)
Steven T. Wang, Washington Univ. School of Medicine in St. Louis (United States)
Natalia G. Zhegalova, Washington Univ. School of Medicine in St. Louis (United States)
Walter J. Akers, Washington Univ. School of Medicine in St. Louis (United States)
Mikhail Y. Berezin, Washington Univ. School of Medicine in St. Louis (United States)


Published in SPIE Proceedings Vol. 8587:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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