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Proceedings Paper

Characterization of human breast cancer by scanning acoustic microscopy
Author(s): Di Chen; Eugene Malyarenko; Fedar Seviaryn; Ye Yuan; Mark Sherman; Sudeshna Bandyopadhyay; Gretchen Gierach; Christopher W. Greenway; Elena Maeva; Emil Strumban; Neb Duric; Roman Maev
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Paper Abstract

Objectives: The purpose of this study was to characterize human breast cancer tissues by the measurement of microacoustic properties. Methods: We investigated eight breast cancer patients using acoustic microscopy. For each patient, seven blocks of tumor tissue were collected from seven different positions around a tumor mass. Frozen sections (10 micrometer, μm) of human breast cancer tissues without staining and fixation were examined in a scanning acoustic microscope with focused transducers at 80 and 200 MHz. Hematoxylin and Eosin (H and E) stained sections from the same frozen breast cancer tissues were imaged by optical microscopy for comparison. Results: The results of acoustic imaging showed that acoustic attenuation and sound speed in cancer cell-rich tissue regions were significantly decreased compared with the surrounding tissue regions, where most components are normal cells/tissues, such as fibroblasts, connective tissue and lymphocytes. Our observation also showed that the ultrasonic properties were influenced by arrangements of cells and tissue patterns. Conclusions: Our data demonstrate that attenuation and sound speed imaging can provide biomechanical information of the tumor and normal tissues. The results also demonstrate the potential of acoustic microscopy as an auxiliary method for operative detection and localization of cancer affected regions.

Paper Details

Date Published: 29 March 2013
PDF: 6 pages
Proc. SPIE 8675, Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy, 86750M (29 March 2013); doi: 10.1117/12.2008660
Show Author Affiliations
Di Chen, Karmanos Cancer Institute (United States)
Eugene Malyarenko, Karmanos Cancer Institute (United States)
Fedar Seviaryn, Karmanos Cancer Institute (United States)
Univ. of Windsor (Canada)
Ye Yuan, Karmanos Cancer Institute (United States)
Univ. of Windsor (Canada)
Mark Sherman, National Cancer Institute (United States)
Sudeshna Bandyopadhyay, Wayne State Univ. School of Medicine (United States)
Gretchen Gierach, National Cancer Institute (United States)
Christopher W. Greenway, Karmanos Cancer Institute (United States)
Elena Maeva, Univ. of Windsor (Canada)
Emil Strumban, Karmanos Cancer Institute (United States)
Univ. of Windsor (Canada)
Neb Duric, Karmanos Cancer Institute (United States)
Roman Maev, Karmanos Cancer Institute (United States)
Univ. of Windsor (Canada)


Published in SPIE Proceedings Vol. 8675:
Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy
Johan G. Bosch; Marvin M. Doyley, Editor(s)

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