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Proceedings Paper

Time-resolved 3D imaging of fluorescent objects in turbid media
Author(s): Jun Wu; Yang Wang; Lev T. Perelman; Irving Itzkan; Ramachandra R. Dasari; Michael S. Feld
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Paper Abstract

We present a single-ended technique for three-dimensional imaging of objects embedded in a turbid medium using time-resolved fluorescence emission. The technique employs the earliest- arriving photons, which we show are not sensitive to the relatively long fluorescence lifetime and thus can be used to provide accurate spatial information even at a distance equivalent to 100 mean free paths (mfps). Experiments to combine fluorescence spectroscopy with time- resolved optical tomography are also presented. In addition, with the aid of the multichannel detection of a streak camera, we are able to accurately localize an embedded fluorescent object in a single measurement. Application of time-resolved Raman spectroscopy is also explored.

Paper Details

Date Published: 31 January 1995
PDF: 5 pages
Proc. SPIE 2326, Photon Transport in Highly Scattering Tissue, (31 January 1995); doi: 10.1117/12.200864
Show Author Affiliations
Jun Wu, Massachusetts Institute of Technology (United States)
Yang Wang, Massachusetts Institute of Technology (United States)
Lev T. Perelman, Massachusetts Institute of Technology (United States)
Irving Itzkan, Massachusetts Institute of Technology (United States)
Ramachandra R. Dasari, Massachusetts Institute of Technology (United States)
Michael S. Feld, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 2326:
Photon Transport in Highly Scattering Tissue

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