Share Email Print

Proceedings Paper

Bioanalytics using single plasmonic nanostructures
Author(s): O. Stranik; T. Schneider; N. Jahr; J. Wirth; F. Garwe; A. Csaki; W. Fritzsche
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Plasmonic nanostructures promise to provide sensing capabilities with the potential for sensitive and robust assays in a high parallelization. We present here the use of individual nanostructures for the detection and manipulation of biomolecules such as DNA based on optical approaches [1]. The change in localized surface plasmon resonance of individual metal nanoparticles is utilized to monitor the binding of DNA directly or via DNA-DNA interaction. The influence of different size (length) as well as position (distance to the particle surface) is thereby studied [2]. Holes in a Cr layer present another interesting approach for bioanalytics. They are used to detect plasmonic nanoparticles as labels or to sense the binding of DNA on these particles. This hybrid system of hole and particle allows for simple (just using RGB-signals of a CCD [3]) but a highly sensitive (one nanoparticle sensitivity) detection. On the other hand, the binding of molecular layers around the particles can be detected using spectroscopic features of just an individual one of these systems. Besides sensing, individual plasmonic nanostructures can be also used to manipulate single biomolecular structures such as DNA. Attached particles can be used for local destruction [4] or cutting as well as coupling of energy into (and guiding along) the molecular structure [5].

Paper Details

Date Published: 22 February 2013
PDF: 7 pages
Proc. SPIE 8595, Colloidal Nanocrystals for Biomedical Applications VIII, 85950C (22 February 2013); doi: 10.1117/12.2008222
Show Author Affiliations
O. Stranik, Institut für Photonische Technologien (Germany)
T. Schneider, Institut für Photonische Technologien (Germany)
N. Jahr, Institut für Photonische Technologien (Germany)
J. Wirth, Institut für Photonische Technologien (Germany)
F. Garwe, Institut für Photonische Technologien (Germany)
A. Csaki, Institut für Photonische Technologien (Germany)
W. Fritzsche, Institut für Photonische Technologien (Germany)

Published in SPIE Proceedings Vol. 8595:
Colloidal Nanocrystals for Biomedical Applications VIII
Wolfgang J. Parak; Marek Osinski; Kenji Yamamoto, Editor(s)

© SPIE. Terms of Use
Back to Top