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Proceedings Paper

Optical imaging via biological object internal structure contrasting
Author(s): Vitaly M. Podgaetsky; Sergei A. Tereshchenko; Nikolai S. Vorobiev; Larisa G. Tomilova; Alexander V. Smirnov; Andrei V. Ivanov
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Paper Abstract

For successful application of laser tomography methods for earlier medical diagnostics the signal-to-noise ratio (contrast) must be increased. For this purpose it is possible to use the absorbing dyes. We have theoretically investigated optical imaging conditions in high scattering medium on a model object. In our experiments a YAG:Nd laser generating picosecond pulses was employed. Output radiation has been recorded by a high speed streak camera with 1.5 ps temporal resolution. The high stability of the laser and of measurement scheme characteristics was provided. We looked for the contrasting substances having tropism with pathologically changed tissue of the tumor. For this purpose some dyphthalocyanines were synthesized. The experiments with laboratory animals have demonstrated that saturated dye concentrations were noticeably lower than toxicologic dangerous concentration values. We have demonstrated a possibility of the contrasting for a model object. The experimental temporal profile of scattered radiation can be explained by the nonstationary two-flow theory.

Paper Details

Date Published: 31 January 1995
PDF: 9 pages
Proc. SPIE 2326, Photon Transport in Highly Scattering Tissue, (31 January 1995); doi: 10.1117/12.200816
Show Author Affiliations
Vitaly M. Podgaetsky, Moscow Institute of Organic Intermediates and Dyes (Russia)
Sergei A. Tereshchenko, Moscow State Institute of Electronic Engineering (Russia)
Nikolai S. Vorobiev, General Physics Institute (Russia)
Larisa G. Tomilova, Moscow Institute of Organic Intermediates and Dyes (Russia)
Alexander V. Smirnov, General Physics Institute (Russia)
Andrei V. Ivanov, Cancer Research Ctr. (Russia)

Published in SPIE Proceedings Vol. 2326:
Photon Transport in Highly Scattering Tissue
Sigrid Avrillier; Britton Chance; Gerhard J. Mueller; Alexander V. Priezzhev; Valery V. Tuchin, Editor(s)

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